" ...  Donovan’s team found that THCA, which they termed "TD," for "truth drug,"  induced "a great loquacity and hilarity," and even, in cases where the subject  didn’t feel physically threatened, some useable "reefer madness." Peyote,  morphine and scopolamine were judged too powerful to be used in effective  interrogation. In light of all this, Donovan concluded, "The drug defies all but  the most expert and search analysis, and for all practical purposes can be  considered beyond analysis." The OSS did not, however, end the program. By that  time, faced with the terrifying ship losses the USA was suffering from German  U-boats, Donovan pressed on, hoping to find some effective chemical means to  help interrogate captured U-boat sailors. 
 In May  1943, George Hunter White, an Army captain, OSS officer and former FBN agent,  gave standard cigarettes laced with THCA to an unwitting August "Augie Dallas"  Del Grazio, an influential New York City gangster. Del Grazio, who had by then  had done prison stretches for assault and murder, had been one of the Mafia’s  most notorious enforcers and narcotics smugglers. He operated an opium alkaloid  factory in Turkey and was a key participant in the long-running  Istanbul/Marsellies/NYC heroin pipeline commonly known as the "French  Connection." Influenced by the THC, Del Grazio (who was also helping to smuggle  spies and Mafiosi into German-occupied Italy) revealed volumes of vital  information about underworld operations, including the names of several high  ranking city and state officials who took bribes from the Mob. Donovan was  encouraged by the results of White’s tests when he wrote, "Cigarette experiments  indicated that we had a mechanism offering promise in relaxing prisoners to be  interrogated." 
 Unsurprisingly, the extensive wartime German experiments with various  hallucinogenic drugs at the Dachau concentration camp, directed by one Dr.  Hubertus Strughold, later honored as "the father of aviation medicine," aroused  great interest in the USA especially after an October 1945 Navy technical  mission to Dachau reported in detail on Strughold’s work. So great, in fact,  that when the OSS and its successor, the CIA, imported 800 German scientists of  various specialties under the auspices of the infamous "Project Paperclip"  during 1945-55, it made sure to include Dr. Strughold. 
 Dr.  Strughold’s barbaric "medical experiments," for which his subordinates were  tried and convicted as war criminals at Nuremburg, were nothing more than a  series of bizarre and unspeakably brutal tortures. Even so, he learned a lot  about human behavior and mescaline, a natural alkaloid present in the peyote  cactus. Mescaline, long central to many Native American religious rituals and  first chemically isolated in 1896, is a phenethylamine whose ergoline skeleton  is also contained in lysergic acid (a tryptamine.) 
 Sandoz  Labs chemist Dr. Albert Hofmann also discovered a lysergic acid derivative  called ergonovine, a medication used to retard excessive postpartum uterine  bleeding. Based on his work with ergonovine, Dr. Hofmann first derived  d-lysergic acid diethylamide tartrate-25 (LSD, a refined alkaloidal liquid  byproduct of a rye fungus, ergot) in a series of experiments in Zurich in 1938.  He used the naturally occurring lysergic acid radical, the common item in all  ergot alkaloids, as the major component of the substance. Further experiments in  this vein yielded psilocybin, derived from the Mexican Psilocybe cubensis  mushroom, hydergine, essential today in the improvement of cerebral circulation  in geriatric patients, and dihydroergotamine, an important ingredient in blood  pressure medication. 
 The  well-read and broadly educated Dr. Hofmann knew ergot had a long natural and  cultural history as both medicine and poison. Ancient Greek midwives used to  give an ergot-based, gruel-like drink, called kykeon, to their patients about to  give birth. Kykeon was also consumed during the autumn Eleusinia, the ancient  Greek agricultural festival celebrated in honor of the goddess of agriculture,  Demeter. Across the Atlantic, sacramental Maya morning glories, beautifully  depicted at the ancient Mayan temple-palace complex at Teotihuacán, Mexico,  dating to about 1450, also contain ergot-based alkaloids. 
 However, the mindset the CIA had in its drug research work was far  different from that of Dr. Hofmann’s. To our Cold War spymasters, ex-Nazis like  Dr. Strughold were definitely evil, but they were definitely useful as well.  This pervasive amoral pragmatism led, of course, to the extensive and notorious  MK-ULTRA experiments in which, for nearly 25 years, thousands of everyday  Americans, both military and civilian, were heavily dosed with numerous very  potent artificial psychoactive drugs, often without their knowledge or consent.  
 This  phenomenon of the obsessive "interests of national security" expediency combined  with our celebrity-obsessed pop culture that gleefully raises and shamelessly  promotes snake oil hustlers as well as the pharmaceutical industry’s pricey  "pill for every ill" philosophy, was a form of incompetence and arrogance far  more hazardous than any synthetic alkaloid ever developed and came as no  surprise to those like Dr. Hofmann. LSD, invaluable in psychiatric treatment –  actor Cary Grant was cured of alcoholism by carefully administered doses of the  drug under close medical supervision – is thousands of times more potent than  the traditional herbal mixtures. In fact, it is thousands of times more potent  than the milder of the entheogenic alkaloids. It is effective at doses of as  little as a ten-millionth of a gram, which makes it 5,000 times more potent than  mescaline. It should not be taken without training or supervision. 
 The  Navy tested mescaline as part of its 1947-53 Project CHATTER. MK-ULTRA was first  organized in 1949 by Richard Helms under the direction of Allen Dulles as  Project BLUEBIRD. Two years later, it was renamed ARTICHOKE (after one of  Dulles’s favorite foods) then termed MK-ULTRA in 1953, finally becoming  MK-SEARCH in 1965 until the program's "official termination" eight years later.  MK-ULTRA was directly responsible for the wide underground availability of LSD,  phencyclidine (PCP – also called "angel dust"), dimethyltryptamine (DMT),  2,5-dimethoxy-4-methylamphetamine (STP) and other powerful synthetic  psychoactive drugs in the 1960s. In the early 1950s, the CIA and the Army had  contacted Sandoz requesting several kilograms of LSD for use in the test  program. Dr. Hofmann and Sandoz refused this request, so Director Dulles  persuaded the Indianapolis-based pharmaceutical luminary Eli Lilly (later the  pioneers of and chief cheerleaders for the widely prescribed antidepressant  Prozac) to synthesize the drug contrary to existing international patent  accords--making the US government and Lilly the first illegal domestic  manufacturers and distributors of LSD. 
 These  were distributed via the agency’s sometime allies in organized crime and through  the FBI’s counterintelligence programs (COINTELPROs) directed against various  activist groups of the period. The actual definition of the term MK-ULTRA  remains unclear but a former Army Special Forces captain, John McCarthy, who ran  the CIA’s Saigon-based Operation Cherry which targeted the Cambodian ruler  Prince Sihanouk for assassination, claimed that MK-ULTRA stood for  "Manufacturing Killers Utilizing Lethal Tradecraft Requiring Assassination." ...  "
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