The wheels of science grind very slowly. Finally, the first half of the work that was the subject of Jennifer Luke's Ph.D. thesis; presentation in Bellingham, Washington (ISFR conference) in 1998 and a videotaped interview I had with her (see www.fluoridealert.org/videos.htm), has been published in Caries Research.
In my view this work is of enormous importance and could be (or should be) the scientific straw that breaks the camel's back of fluoridation.
When Luke found out that the pineal gland - a little gland in the center of the brain, responsible for a very large range of regulating activities (it produces serotonin and melatonin) - was also a calcifying tissue, like the teeth and the bones, she hypothesized it would concentrate fluoride to very high levels. The gland is not protected by the blood brain barrier and has a very high perfusion rate of blood, second only to the kidney.
Luke had 11 cadavers analyzed in the UK. As she predicted she found astronomically high levels of fluoride in the calcium hydroxy apatite crystals produced by the gland. The average was 9000 ppm and went as high as 21,000 in one case. These levels are at, or higher, than fluoride levels in the bones of people suffering from skeletal fluorosis. It is these findings which have just been published.
It is the ramifications of these findings which have yet to be published. In the second half of her work she treated animals (Mongolian gerbils) with fluoride at a crack pineal gland research unit at the University of Surrey, UK (so there is no question about the quality of this work). She found that melatonin production (as measured by the concentration of a melatonin metabolite in the urine) was lower in the animals treated with high fluoride levels compared with those treated with low levels.
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Wouldn't it be better, if somebody does a proper study on a large Number of population in an area where natural water has a higher concentration of fluoride or more incidence of flurosis to substantiate this?
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