Those women left a particular DNA legacy that persists to today in about 95 percent of Indians, researchers said.
The finding does not mean that only these six women gave rise to the migrants who crossed into North America from Asia in the initial populating of the continent, said study co-author Ugo Perego.
The women lived between 18,000 and 21,000 years ago, though not necessarily at exactly the same time, he said.
The work was published this week by the journal PLoS One. Perego is from the Sorenson Molecular Genealogy Foundation in Salt Lake City and the University of Pavia in Italy.
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